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Tesofensine is a triple monoamine reuptake inhibitor (serotonin, noradrenaline, dopamine) extensively studied in pre-clinical models of appetite regulation, energy expenditure, and central reward pathways

It's best to follow their directions and use this article as a refresher

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It would be advisable to tell him / her that you have supplemented with B12 (since a high serum B12 level, in the ABSENCE of supplementation, can be indicative of other serious conditions, so your GP will need to know that the high level is probably due to supplements)